[HTML][HTML] Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

M Gratuze, CEG Leyns, AD Sauerbeck… - The Journal of …, 2020 - Am Soc Clin Investig
Alzheimer’s disease (AD) is characterized by plaques containing amyloid-β (Aβ) and
neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau and Aβ, …

Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice

…, RN Bannon, AD Sauerbeck… - Proceedings of the …, 2021 - National Acad Sciences
Heterozygous genetic variants within the TREM2 gene show a strong association with
increased Alzheimer’s disease (AD) risk. Amyloid beta–depositing mouse models …

Spinal cord injury causes chronic liver pathology in rats

AD Sauerbeck, JL Laws, VVR Bandaru… - Journal of …, 2015 - liebertpub.com
Traumatic spinal cord injury (SCI) causes major disruption to peripheral organ innervation
and regulation. Relatively little work has investigated these post-SCI systemic changes, …

[PDF][PDF] Neuronal VCP loss of function recapitulates FTLD-TDP pathology

A Wani, J Zhu, JD Ulrich, A Eteleeb, AD Sauerbeck… - Cell reports, 2021 - cell.com
The pathogenic mechanism by which dominant mutations in VCP cause multisystem
proteinopathy (MSP), a rare neurodegenerative disease that presents as fronto-temporal lobar …

[HTML][HTML] Mitochondria, amyloid β, and Alzheimer's disease

RD Readnower, AD Sauerbeck… - International Journal of …, 2011 - hindawi.com
Hypometabolism is a hallmark of Alzheimer's disease (AD) and implicates a mitochondrial
role in the neuropathology associated with AD. Mitochondrial amyloid-beta (Aβ) accumulation …

[PDF][PDF] SEQUIN multiscale imaging of mammalian central synapses reveals loss of synaptic connectivity resulting from diffuse traumatic brain injury

AD Sauerbeck, M Gangolli, SJ Reitz, MH Salyards… - Neuron, 2020 - cell.com
The brain's complex microconnectivity underlies its computational abilities and vulnerability
to injury and disease. It has been challenging to illuminate the features of this synaptic …

Liver inflammation at the time of spinal cord injury enhances intraspinal pathology, liver injury, metabolic syndrome and locomotor deficits

MT Goodus, KE Carson, AD Sauerbeck, P Dey… - Experimental …, 2021 - Elsevier
The current high obesity rates mean that neurological injuries are increasingly sustained on
a background of systemic pathology, including liver inflammation, which likely has a …

Sex differences in the role of CNIH3 on spatial memory and synaptic plasticity

…, SB Williams, CR Trousdale, MY Sun, AD Sauerbeck… - Biological …, 2021 - Elsevier
Background CNIH3 is an AMPA receptor (AMPAR) auxiliary protein prominently expressed
in the dorsal hippocampus (dHPC), a region that plays a critical role in spatial memory and …

[HTML][HTML] Diffusion basis spectrum imaging detects subclinical traumatic optic neuropathy in a closed-head impact mouse model of traumatic brain injury

HC Yang, RS Lavadi, AD Sauerbeck… - Frontiers in …, 2023 - frontiersin.org
Introduction Traumatic optic neuropathy (TON) is the optic nerve injury secondary to brain
trauma leading to visual impairment and vision loss. Current clinical visual function …

Dietary green tea extract prior to spinal cord injury prevents hepatic iron overload but does not improve chronic hepatic and spinal cord pathology in rats

MT Goodus, AD Sauerbeck, PG Popovich… - Journal of …, 2018 - liebertpub.com
Spinal cord injury (SCI) disrupts autonomic regulation of visceral organs. As a result, a leading
cause of mortality in the SCI population is metabolic dysfunction, and an organ central to …