Perilipin-2 (PLIN2) is a constitutively associated cytoplasmic lipid droplet coat protein that
has been implicated in fatty liver formation in non-alcoholic fatty liver disease. Mice with or …

Key points Wild‐type mice and mice with hepatocyte‐specific or whole‐body deletions of
perilipin‐2 (Plin2) were used to define hepatocyte and extra‐hepatocyte effects of altered …

Fluorescence microscopy, in particular immunofluorescence microscopy, has been used
extensively for the assessment of kidney function and pathology for both research and …

Over the last 30 years, nuclear receptors (NRs) have been increasingly recognized as key
modulators of systemic homeostasis and as contributing factors in many diseases. In the …

Nonalcoholic fatty liver disease is a rapidly rising problem in the 21st century and is a leading
cause of chronic liver disease that can lead to end-stage liver diseases, including cirrhosis …

Background/Objectives The current obesity epidemic has spurred exploration of the
developmental origin of adult heath and disease. A mother’s dietary choices and health can affect …

Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the US,
partly due to the increasing incidence of metabolic syndrome, obesity, and type 2 diabetes. …

Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver
induced by Western or high-fat diets. In the current study, we found that, compared with WT …

LPL is the rate-limiting enzyme for uptake of TG-derived FFA in peripheral tissues, and the
enzyme is expressed in the brain and CNS. We previously created a mouse which lacks …

Loss of ovarian function imparts increased susceptibility to obesity and metabolic disease.
These effects are largely attributed to decreased estradiol (E 2 ), but the role of increased …