User profiles for Andrew E. Teschendorff
 | Andrew TeschendorffCAS Key Lab of Computational Biology Institute, Shanghai & University College London Verified email at picb.ac.cn Cited by 26228 |
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
CS Ross-Innes, R Stark, AE Teschendorff, KA Holmes… - Nature, 2012 - nature.com
Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
Motivation: The Illumina Infinium 450 k DNA Methylation Beadchip is a prime candidate
technology for Epigenome-Wide Association Studies (EWAS). However, a difficulty associated …
technology for Epigenome-Wide Association Studies (EWAS). However, a difficulty associated …
[HTML][HTML] MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
Background MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants
and animals, often act post-transcriptionally to inhibit gene expression. Results Here we …
and animals, often act post-transcriptionally to inhibit gene expression. Results Here we …
[HTML][HTML] Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
Recent advances in next generation sequencing 1 , 2 , 3 , 4 have made it possible to
precisely characterize all somatic coding mutations that occur during the development and …
precisely characterize all somatic coding mutations that occur during the development and …
ChAMP: 450k chip analysis methylation pipeline
TJ Morris, LM Butcher, A Feber, AE Teschendorff… - …, 2014 - academic.oup.com
The Illumina Infinium HumanMethylation450 BeadChip is a new platform for high-throughput
DNA methylation analysis. Several methods for normalization and processing of these data …
DNA methylation analysis. Several methods for normalization and processing of these data …
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
AE Teschendorff, U Menon, A Gentry-Maharaj… - Genome …, 2010 - genome.cshlp.org
Polycomb group proteins (PCGs) are involved in repression of genes that are required for
stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) …
stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) …
ChAMP: updated methylation analysis pipeline for Illumina BeadChips
The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high-throughput
DNA methylation analysis, effectively doubling the coverage compared to the older 450 …
DNA methylation analysis, effectively doubling the coverage compared to the older 450 …
[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
[HTML][HTML] An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
AE Teschendorff, A Miremadi, SE Pinder, IO Ellis… - Genome biology, 2007 - Springer
Background Estrogen receptor (ER)-negative breast cancer specimens are predominantly
of high grade, have frequent p53 mutations, and are broadly divided into HER2-positive and …
of high grade, have frequent p53 mutations, and are broadly divided into HER2-positive and …
Menopause accelerates biological aging
Although epigenetic processes have been linked to aging and disease in other systems, it is
not yet known whether they relate to reproductive aging. Recently, we developed a highly …
not yet known whether they relate to reproductive aging. Recently, we developed a highly …