Simple Summary Protein phosphorylation is a key regulatory mechanism that controls a
wide variety of cellular responses. This process is catalysed by the members of the protein …

The ErbB family of transmembrane tyrosine kinases includes the receptor for EGF (ErbB-1),
two receptors for NDF/heregulin (ErbB-3 and ErbB-4) and an orphan receptor (ErbB-2). In …

Eph receptor tyrosine kinases and their ligands, ephrins, are membrane proteins coordinating
a wide range of biological functions both in developing embryos and in adult multicellular …

Metabolic alterations play an important role in cancer and yet, few metabolic cancer driver
genes are known. Here we perform a combined genomic and metabolic modeling analysis …

Both CD4 + Th17-cells and CD8 + cytotoxic T lymphocytes (CTLs) are involved in type 1
diabetes and experimental autoimmune encephalomyelitis (EAE). However, their relationship in …

Eph receptor tyrosine kinases and their ligands, the ephrins, are known to play an important
role in regulating cell migration and targeting in neuronal and endothelial cells. Recently, it …

Uniquely for the Eph family of receptor tyrosine kinases, the EphB6 receptor is catalytically
inactive due to the alteration of several critical residues in its kinase domain. This has cast …

Cancer invasiveness plays a major role in the mortality of patients with solid tumors, and
deregulated cell adhesion and migration are suspected to drive invasive behavior. Since Eph …

Simulated microgravity (SMG) was reported to affect tumor cell proliferation and metastasis.
However, the underlying mechanism is elusive. In this study, we demonstrate that clinostat-…

Progressive interaction with other cells is critical to all aspects of T-cell biology – from
migration through tissues, to recognition of antigen-presenting cells. We demonstrate a novel …