User profiles for Andrew Fribley
Andrew FribleyWayne State University Verified email at med.wayne.edu Cited by 2386 |
Wnt-1 signaling inhibits apoptosis by activating β-catenin/T cell factor–mediated transcription
Wnt signaling plays a critical role in development and oncogenesis. Although significant
progress has been made in understanding the downstream signaling cascade of Wnt signaling, …
progress has been made in understanding the downstream signaling cascade of Wnt signaling, …
Regulation of apoptosis by the unfolded protein response
A Fribley, K Zhang, RJ Kaufman - Apoptosis: Methods and Protocols …, 2009 - Springer
In eukaryotic cells, the endoplasmic reticulum (ER) serves many specialized functions including
bio-synthesis and assembly of membrane and secretory proteins, calcium storage and …
bio-synthesis and assembly of membrane and secretory proteins, calcium storage and …
Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress
The 26S proteasome is a large multi-subunit protein complex found in the cytoplasm and
nucleus of mammalian cells which plays a critical role in intracellular proteolysis. It has been …
nucleus of mammalian cells which plays a critical role in intracellular proteolysis. It has been …
Topical agents for oral cancer chemoprevention: A systematic review of the literature
Objectives/hypothesis We review the use of topical chemoprevention agents in patients with
oral potentially malignant disorders (PMD). Methods A systematic review of studies on …
oral potentially malignant disorders (PMD). Methods A systematic review of studies on …
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell …
PS-341, also known as Velcade or Bortezomib, represents a new class of anticancer drugs
which has been shown to potently inhibit the growth and/or progression of human cancers, …
which has been shown to potently inhibit the growth and/or progression of human cancers, …
[HTML][HTML] Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa
AM Fribley, B Evenchik, Q Zeng, BK Park… - Journal of Biological …, 2006 - ASBMB
Cisplatin is one of the most common DNA-damaging agents used for treating patients with
solid tumors such as squamous cell carcinoma (SCC). Unfortunately, significant levels of …
solid tumors such as squamous cell carcinoma (SCC). Unfortunately, significant levels of …
Celastrol induces unfolded protein response-dependent cell death in head and neck cancer
AM Fribley, JR Miller, AL Brownell, DM Garshott… - Experimental cell …, 2015 - Elsevier
The survival rate for patients with oral squamous cell carcinoma (OSCC) has not seen
marked improvement in recent decades despite enhanced efforts in prevention and the …
marked improvement in recent decades despite enhanced efforts in prevention and the …
Systemic therapy for head and neck squamous cell carcinoma: Historical perspectives and recent breakthroughs
…, P Saraf, JA Eloy, S Baredes, AM Fribley - The …, 2017 - Wiley Online Library
Objectives Despite dramatic developments in drugs established for other malignancies,
historically there have been few novel systemic agents available for the management of head …
historically there have been few novel systemic agents available for the management of head …
Head and neck cancer: underfunded and understudied?
…, GH Yoo, AJ Folbe, HS Lin, AM Fribley - … –Head and Neck …, 2017 - journals.sagepub.com
Despite a considerable expansion in our therapeutic repertoire for management of other
malignancies, mortality from head and neck cancer (HNC) has not significantly improved in …
malignancies, mortality from head and neck cancer (HNC) has not significantly improved in …
Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response
AM Fribley, PG Cruz, JR Miller… - Journal of …, 2011 - journals.sagepub.com
Despite advances toward understanding the prevention and treatment of many cancers,
patients who suffer from oral squamous cell carcinoma (OSCC) confront a survival rate that has …
patients who suffer from oral squamous cell carcinoma (OSCC) confront a survival rate that has …