Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has been …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

SOCS-1 was originally identified as an inhibitor of interleukin-6 signal transduction and is a
member of a family of proteins (SOCS-1 to SOCS-7 and CIS) that contain an SH2 domain …

To identify cell-surface markers specific to human cardiomyocytes, we screened cardiovascular
cell populations derived from human embryonic stem cells (hESCs) against a panel of …

Human pluripotent stem cells are a powerful tool for modeling brain development and disease.
The human cortex is composed of two major neuronal populations: projection neurons …

Directed differentiation from human pluripotent stem cells (hPSCs) has seen significant progress
in recent years. However, most differentiated populations exhibit immature properties of …

The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development or …

Organoid techniques provide unique platforms to model brain development and neurological
disorders. Whereas several methods for recapitulating corticogenesis have been described…

NKX2-5 is expressed in the heart throughout life. We targeted eGFP sequences to the NKX2-5
locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …

To realize the therapeutic potential of human embryonic stem cells (hESCs), it is necessary
to regulate their differentiation in a uniform and reproducible manner. We have developed a …