Several studies have examined the link between the cannabinoid CB1 receptor and several
neuropsychiatric illnesses, including schizophrenia. As such, there is a need for in vivo …

While neuroinflammation is an evolving concept and the cells involved and their functions
are being defined, microglia are understood to be a key cellular mediator of brain injury and …

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular
chemogenetic technology for manipulation of neuronal activity in uninstrumented awake …

Assays of human postmortem brain tissue have revealed that smokers have greater densities
of high-affinity nicotinic acetylcholine receptors (nAChRs) in several brain regions than do …

Exploration of the central CB 1 cannabinoid receptors using positron emission tomography (PET)
will allow for an understanding of the pharmacological and physiological role played …

In Alzheimer’s disease (AD), one of the early responses to Aβ amyloidosis is recruitment of
microglia to areas of new plaque. Microglial receptors such as cannabinoid receptor 2 (CB2) …

Recently, A-836339 [2,2,3,3-tetramethylcyclopropanecarboxylic acid [3-(2-methoxyethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]amide]
(1) was reported to be a selective CB 2 agonist …

In an effort to develop selective radioligands for in vivo imaging of neuronal nicotinic
acetylcholine receptors (nAChRs), we synthesized 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5-…

The development of the radioligands for PET imaging of the cerebral cannabinoid receptor (CB1)
is of great importance for studying its role in neuropsychiatric disorders, obesity, and …

The alpha-7 subtype of the nicotinic acetylcholine receptor (α7-nAChR) is fundamental to
physiology; it mediates various brain functions and represents an important target for drug …