Genotype to phenotype relationships in autism spectrum disorders
J Chang, SR Gilman, AH Chiang, SJ Sanders… - Nature …, 2015 - nature.com
Autism spectrum disorders (ASDs) are characterized by phenotypic and genetic heterogeneity.
Our analysis of functional networks perturbed in ASD suggests that both truncating and …
Our analysis of functional networks perturbed in ASD suggests that both truncating and …
[HTML][HTML] Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data
…, AH Chiang, SMA Tabei, H Gudjonson… - PLoS computational …, 2015 - journals.plos.org
Robust methods for identifying patterns of expression in genome-wide data are important for
generating hypotheses regarding gene function. To this end, several analytic methods have …
generating hypotheses regarding gene function. To this end, several analytic methods have …
A negative feedback loop mediated by the Bcl6–cullin 3 complex limits Tfh cell differentiation
R Mathew, A Mao, AH Chiang… - Journal of Experimental …, 2014 - rupress.org
Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh) cell differentiation
of antigen-stimulated CD4 + T cells. Intriguingly, we found that Bcl6 was also highly and …
of antigen-stimulated CD4 + T cells. Intriguingly, we found that Bcl6 was also highly and …
Global measures of impairment for epidemiologic and clinical use with children and adolescents.
HR Bird, H Andrews, M Schwab-Stone… - … Journal of Methods in …, 1996 - psycnet.apa.org
Evaluated the validity of lay interviewer and parent ratings on the Children's Global
Assessment Scale (CGAS) and parent and youth forms of the Columbia Impairment Scale (CIS). …
Assessment Scale (CGAS) and parent and youth forms of the Columbia Impairment Scale (CIS). …
Exons as units of phenotypic impact for truncating mutations in autism
Autism spectrum disorders (ASD) are a group of related neurodevelopmental diseases
displaying significant genetic and phenotypic heterogeneity. Despite recent progress in …
displaying significant genetic and phenotypic heterogeneity. Despite recent progress in …
Conceptual and experimental tools to understand spatial effects and transport phenomena in nonlinear biochemical networks illustrated with patchy switching
RR Pompano, AH Chiang, CJ Kastrup… - Annual review of …, 2017 - annualreviews.org
Many biochemical systems are spatially heterogeneous and exhibit nonlinear behaviors,
such as state switching in response to small changes in the local concentration of diffusible …
such as state switching in response to small changes in the local concentration of diffusible …
LSST: from science drivers to reference design and anticipated data products
Major advances in our understanding of the universe have historically arisen from dramatic
improvements in our ability to “see.” We have developed progressively larger telescopes …
improvements in our ability to “see.” We have developed progressively larger telescopes …
LSST: from science drivers to reference design and anticipated data products
We describe here the most ambitious survey currently planned in the optical, the Large
Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: …
Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: …
[BOOK][B] Mechanisms Underlying Phenotypic Heterogeneity in Simplex Autism Spectrum Disorders
AH Chiang - 2021 - search.proquest.com
Autism spectrum disorders (ASD) are a group of related neurodevelopmental diseases
displaying significant genetic and phenotypic heterogeneity. Despite recent progress in ASD …
displaying significant genetic and phenotypic heterogeneity. Despite recent progress in ASD …
[PDF][PDF] Intellectual phenotypes in autism strongly correlate with gene dosage changes and exon locations of truncating mutations
AH Chiang, J Chang, D Vitkup - scholar.archive.org
Autism spectrum disorders (ASD) are a group of related neurodevelopmental diseases
displaying significant genetic and phenotypic heterogeneity1-4. Despite recent progress in …
displaying significant genetic and phenotypic heterogeneity1-4. Despite recent progress in …