Scalloped (Sd) and Vestigial (Vg) are each needed forDrosophila wing development. We
show that Sd is required for Vg function and that altering their relative cellular levels inhibits …

The innate immune response is critical for animal homeostasis and is conserved from
invertebrates to vertebrates. This response depends on specialized cells that recognize, internalize…

Many developing and adult tissues are comprised of polarized epithelia. Proteins that are
asymmetrically distributed in these cells are thought to be localized by protein trafficking. Here …

SUBDIVISION of the limb primordia into compartments initiates pattern formation in the
developing limbs 1,2 . Interaction between distinctly specific cells in adjacent compartments leads …

Human peroxisome biogenesis disorders are lethal genetic diseases in which abnormal
peroxisome assembly compromises overall peroxisome and cellular function. Peroxisomes are …

Aging is characterized by a chronic, low-grade inflammation, which is a major risk factor for
cardiovascular diseases. It remains poorly understood whether pro-inflammatory factors …

… Hobman, John Locke, Andrew J. Simmonds; Gawky is a component of cytoplasmic mRNA
processing bodies required for early Drosophila development . J Cell Biol 31 July 2006; 174 (3…

Phagocytosis, signal transduction, and inflammatory responses require changes in lipid
metabolism. Peroxisomes have key roles in fatty acid homeostasis and in regulating immune …

The gut has a central role in digestion and nutrient absorption, but it also serves in defending
against pathogens, engages in mutually beneficial interactions with commensals, and is a …

To activate transcription, most nuclear receptor proteins require coactivators that bind to
their ligand‐binding domains (LBDs). The Drosophila FTZ‐Factor1 (FTZ‐F1) protein is a …