INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (…

Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a minority of
children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might …

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing …

Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines
underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, …

The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is
initiated by recognition of ligand followed by oligomerization into a higher order signaling …

Nuclear factor-κB (NF-κB) controls genes involved in normal lymphocyte functions, but
constitutive NF-κB activation is often associated with B cell malignancy. Using high-throughput …

Few monogenic causes for severe manifestations of common allergic diseases have been
identified. Through next-generation sequencing on a cohort of patients with severe atopic …

… Andrew L. Snow … Snow, Rebecca A. Marsh; X-linked lymphoproliferative syndromes:
brothers or distant cousins?. Blood 2010; 116 (18): 3398–3408. …

X-linked lymphoproliferative disease (XLP) is a rare congenital immunodeficiency that leads
to an extreme, usually fatal increase in the number of lymphocytes upon infection with EBV. …