RNA molecules adopt three-dimensional structures that are critical to their function and of
interest in drug discovery. Few RNA structures are known, however, and predicting them …

Glutamate transporters regulate excitatory neurotransmission and prevent glutamate-mediated
excitotoxicity in the CNS. To better study the cellular and temporal dynamics of the …

AlphaFold2 revolutionized structural biology with the ability to predict protein structures with
exceptionally high accuracy. Its implementation, however, lacks the code and data required …

Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases,
including COVID-19. However, their optimization is hindered by mRNA instability and …

The discovery and design of biologically important RNA molecules is outpacing three-dimensional
structural characterization. Here, we demonstrate that cryo-electron microscopy can …

RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of
RNA 3D structure prediction. With agreement from crystallographers, the RNA structures are …

RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery
and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely …

The development of inhibitors for protein–protein interactions frequently involves the mimicry
of secondary structure motifs. While helical protein–protein interactions have been heavily …

The rapid spread of COVID-19 is motivating development of antivirals targeting conserved
SARS-CoV-2 molecular machinery. The SARS-CoV-2 genome includes conserved RNA …

The 3T3-L1 preadipocyte culture system has been used to examine numerous compounds
that influence adipocyte differentiation or function. The perfluoroalkyl acids (PFAAs), used as …