Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer,
characterized by the presence of inactivating mutations in the VHL gene in most cases 1 , 2 , …

Cancer is driven by somatically acquired point mutations and chromosomal rearrangements,
conventionally thought to accumulate gradually over time. Using next-generation …

COSMIC ( http://www.sanger.ac.uk/cosmic ) curates comprehensive information on somatic
mutations in human cancer. Release v48 (July 2010) describes over 136 000 coding …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …

Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation
is maintained via post-translational modifications of core histones. Here, we describe …

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver
mutations, confer selective growth advantage and are implicated in cancer development, …

Cancer evolves dynamically as clonal expansions supersede one another driven by shifting
selective pressures, mutational processes, and disrupted cancer genes. These processes …