User profiles for Andrew N Holding
Dr Andrew N HoldingAssistant Professor of Biomedical Science (University of York) Verified email at york.ac.uk Cited by 755 |
[HTML][HTML] XL-MS: Protein cross-linking coupled with mass spectrometry
AN Holding - Methods, 2015 - Elsevier
With the continuing trend to study larger and more complex systems, the application of protein
cross-linking coupled with mass spectrometry (XL-MS) provides a varied toolkit perfectly …
cross-linking coupled with mass spectrometry (XL-MS) provides a varied toolkit perfectly …
Web tools to fight pandemics: the COVID-19 experience
The current outbreak of COVID-19 has generated an unprecedented scientific response
worldwide, with the generation of vast amounts of publicly available epidemiological, biological …
worldwide, with the generation of vast amounts of publicly available epidemiological, biological …
[HTML][HTML] A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes
EK Papachristou, K Kishore, AN Holding… - Nature …, 2018 - nature.com
Understanding the dynamics of endogenous protein–protein interactions in complex networks
is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of protein …
is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of protein …
Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein
Cytoplasmic dynein is the major minus end-directed microtubule motor in eukaryotes. However,
there is little structural insight into how different cargos are recognized and linked to the …
there is little structural insight into how different cargos are recognized and linked to the …
KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice
…, HA Beard, B da Silva, AN Holding… - Science translational …, 2018 - science.org
Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a
potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain …
potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain …
[HTML][HTML] Organization of subunits in the membrane domain of the bovine F-ATPase revealed by covalent cross-linking
J Lee, SJ Ding, TB Walpole, AN Holding… - Journal of Biological …, 2015 - ASBMB
The F-ATPase in bovine mitochondria is a membrane-bound complex of about 30 subunits
of 18 different kinds. Currently, ∼85% of its structure is known. The enzyme has a membrane …
of 18 different kinds. Currently, ∼85% of its structure is known. The enzyme has a membrane …
Architecture of the Pol III–clamp–exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair
A Toste Ręgo, AN Holding, H Kent, MH Lamers - The EMBO journal, 2013 - embopress.org
… The mgf files were then imported into Crosslinker, in‐house software that searches deconvoluted
data for pairs of ions within 120 scans of each other and 4 Da apart (Andrew N Holding…
data for pairs of ions within 120 scans of each other and 4 Da apart (Andrew N Holding…
Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq
…, AE Cullen, F Markowetz, AN Holding - Nucleic acids …, 2018 - academic.oup.com
A key challenge in quantitative ChIP combined with high-throughput sequencing (ChIP-seq)
is the normalization of data in the presence of genome-wide changes in occupancy. …
is the normalization of data in the presence of genome-wide changes in occupancy. …
Hekate: software suite for the mass spectrometric analysis and three-dimensional visualization of cross-linked protein samples
AN Holding, MH Lamers, E Stephens… - Journal of proteome …, 2013 - ACS Publications
Chemical cross-linking of proteins combined with mass spectrometry provides an attractive
and novel method for the analysis of native protein structures and protein complexes. …
and novel method for the analysis of native protein structures and protein complexes. …
Forging a field: the golden age of iron biology
NC Andrews - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
… ) and L- (light or liver) types, which can hold up to 4500 iron atoms. As pointed out by Munro,
it … iron-binding lobes, each capable of holding one atom. Lower eukaryotes have transferrins …
it … iron-binding lobes, each capable of holding one atom. Lower eukaryotes have transferrins …