User profiles for Andrew N Holding

Dr Andrew N Holding

Assistant Professor of Biomedical Science (University of York)
Verified email at york.ac.uk
Cited by 755

[HTML][HTML] XL-MS: Protein cross-linking coupled with mass spectrometry

AN Holding - Methods, 2015 - Elsevier
With the continuing trend to study larger and more complex systems, the application of protein
cross-linking coupled with mass spectrometry (XL-MS) provides a varied toolkit perfectly …

Web tools to fight pandemics: the COVID-19 experience

D Mercatelli, AN Holding, FM Giorgi - Briefings in bioinformatics, 2021 - academic.oup.com
The current outbreak of COVID-19 has generated an unprecedented scientific response
worldwide, with the generation of vast amounts of publicly available epidemiological, biological …

[HTML][HTML] A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes

EK Papachristou, K Kishore, AN Holding… - Nature …, 2018 - nature.com
Understanding the dynamics of endogenous protein–protein interactions in complex networks
is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of protein …

Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein

Y Liu, HK Salter, AN Holding, CM Johnson… - Genes & …, 2013 - genesdev.cshlp.org
Cytoplasmic dynein is the major minus end-directed microtubule motor in eukaryotes. However,
there is little structural insight into how different cargos are recognized and linked to the …

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

…, HA Beard, B da Silva, AN Holding… - Science translational …, 2018 - science.org
Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a
potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain …

[HTML][HTML] Organization of subunits in the membrane domain of the bovine F-ATPase revealed by covalent cross-linking

J Lee, SJ Ding, TB Walpole, AN Holding… - Journal of Biological …, 2015 - ASBMB
The F-ATPase in bovine mitochondria is a membrane-bound complex of about 30 subunits
of 18 different kinds. Currently, ∼85% of its structure is known. The enzyme has a membrane …

Architecture of the Pol III–clamp–exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair

A Toste Ręgo, AN Holding, H Kent, MH Lamers - The EMBO journal, 2013 - embopress.org
… The mgf files were then imported into Crosslinker, in‐house software that searches deconvoluted
data for pairs of ions within 120 scans of each other and 4 Da apart (Andrew N Holding

Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq

…, AE Cullen, F Markowetz, AN Holding - Nucleic acids …, 2018 - academic.oup.com
A key challenge in quantitative ChIP combined with high-throughput sequencing (ChIP-seq)
is the normalization of data in the presence of genome-wide changes in occupancy. …

Hekate: software suite for the mass spectrometric analysis and three-dimensional visualization of cross-linked protein samples

AN Holding, MH Lamers, E Stephens… - Journal of proteome …, 2013 - ACS Publications
Chemical cross-linking of proteins combined with mass spectrometry provides an attractive
and novel method for the analysis of native protein structures and protein complexes. …

Forging a field: the golden age of iron biology

NC Andrews - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
… ) and L- (light or liver) types, which can hold up to 4500 iron atoms. As pointed out by Munro,
it … iron-binding lobes, each capable of holding one atom. Lower eukaryotes have transferrins …