Cyclic electron flow around photosystem I (PSI) is a mechanism by which photosynthetic
organisms balance the levels of ATP and NADPH necessary for efficient photosynthesis 1 , 2 . …

Parkinson’s disease (PD) is a degenerative movement disorder resulting from the loss of
specific neuron types in the midbrain. Early environmental and pathophysiological studies …

Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-onset
Parkinson’s disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial quality …

The Parkin co-regulated gene protein (PACRG) binds at the inner junction between doublet
microtubules of the axoneme, a structure found in flagella and cilia. PACRG binds to the …

The generation of mitochondrial-derived vesicles (MDVs) is implicated in a plethora of vital
cell functions, from mitochondrial quality control to peroxisomal biogenesis. The discovery of …

Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the selective loss of
motor neurons leading to paralysis. Mutations in the gene encoding superoxide dismutase 1 (…

Patient-derived organoids from induced pluripotent stem cells have emerged as a model for
studying human diseases beyond conventional two-dimensional (2D) cell culture. Briefly, …

Mitochondrial dysfunction is implicated in a wide array of human diseases ranging from
neurodegenerative disorders to cardiovascular defects. The coordinated localization and import …

Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological
processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged …

Given their polyvalent functions, an inherent challenge that mitochondria face is the exposure
to mitochondrial import stresses, culminating in their dysfunction. Recently, mitochondrial …