With the continuing trend to study larger and more complex systems, the application of protein
cross-linking coupled with mass spectrometry (XL-MS) provides a varied toolkit perfectly …

The current outbreak of COVID-19 has generated an unprecedented scientific response
worldwide, with the generation of vast amounts of publicly available epidemiological, biological …

Understanding the dynamics of endogenous protein–protein interactions in complex networks
is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of protein …

Cytoplasmic dynein is the major minus end-directed microtubule motor in eukaryotes. However,
there is little structural insight into how different cargos are recognized and linked to the …

Pharmacological inhibition of uncontrolled cell growth with small-molecule inhibitors is a
potential strategy for treating glioblastoma multiforme (GBM), the most malignant primary brain …

The F-ATPase in bovine mitochondria is a membrane-bound complex of about 30 subunits
of 18 different kinds. Currently, ∼85% of its structure is known. The enzyme has a membrane …

… The mgf files were then imported into Crosslinker, in‐house software that searches deconvoluted
data for pairs of ions within 120 scans of each other and 4 Da apart (Andrew N Holding…

Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory
interactions of transcription factors by overlaying networks generated from publicly available …

The Estrogen Receptor-alpha (ER) drives 75% of breast cancers. On activation, the ER
recruits and assembles a 1-2 MDa transcriptionally active complex. These complexes can …

… ) and L- (light or liver) types, which can hold up to 4500 iron atoms. As pointed out by Munro,
it … iron-binding lobes, each capable of holding one atom. Lower eukaryotes have transferrins …