There is a general consensus that supports the need for standardized reporting of metadata
or information describing large-scale metabolomics and other functional genomics data sets…

Because MYC plays a causal role in many human cancers, including those with hypoxic and
nutrient-poor tumor microenvironments, we have determined the metabolic responses of a …

In this review, we give an overview of recent literature on the structure and stability of
unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo function. …

Nucleotides are required for a wide variety of biological processes and are constantly
synthesized denovo in all cells. When cells proliferate, increased nucleotide synthesis is …

Background Metabolic perturbations arising from malignant transformation have not been
systematically characterized in human lung cancers in situ. Stable isotope resolved …

Introduction: Background to metabolomics Metabolomics is the comprehensive study of the
metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, …

In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates
glutamine catabolism to fuel growth and proliferation of cancer cells through up-regulating …

Anabolic biosynthesis requires precursors supplied by the Krebs cycle, which in turn requires
anaplerosis to replenish precursor intermediates. The major anaplerotic sources are …

The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate
and lactate, is upregulated in human cancers, and is associated with aggressive tumor …

Introduction Glycolysis is increased in breast adenocarcinoma cells relative to adjacent
normal cells in order to produce the ATP and anabolic precursors required for survival, growth …