The conserved protein-conducting channel, referred to as the Sec61 channel in eukaryotes
or the SecY channel in eubacteria and archaea, translocates proteins across cellular …

The development of neuroprotective strategies to attenuate retinal ganglion cell death could
lead to novel therapies for chronic optic neuropathies such as glaucoma. Intravitreal …

Introduction: Diabetic retinopathy (DR) is the leading cause of vision loss in the working age
population of the developed world. DR encompasses a complex pathology, and one that is …

Adult mammalian central nervous system axons have intrinsically poor regenerative capacity,
so axonal injury has permanent consequences. One approach to enhancing regeneration …

Five species of parasite cause malaria in humans with the most severe disease caused by
Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are …

Background: Clathrin-coated pits are formed at the plasma membrane by the assembly of the
coat components, namely clathrin and adaptors from the cytosol. Little is known about the …

A large class of ATPases contains a RecA-like structural domain and uses the energy of
nucleotide binding and hydrolysis to perform mechanical work, for example, to move …

HIV continues to be transmitted at unacceptably high rates among African Americans, and
most HIV-prevention interventions have focused on behavioral change. To theorize additional …

An important step in the biosynthesis of many proteins is their partial or complete translocation
across the plasma membrane in prokaryotes or the endoplasmic reticulum membrane in …

The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide
substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have …