Vascular endothelial growth factor (VEGF), a potent angiogenic factor and endothelial cell-specific
mitogen, is up-regulated by hypoxia. However, the mechanism(s) responsible for …

Inactivation of the von Hippel-Lindau protein (pVHL) has been implicated in the pathogenesis
of renal carcinomas and central nervous system hemangioblastomas. These are highly …

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor whose expression is
dramatically induced by hypoxia due in large part to an increase in the stability of its mRNA. …

The major control point for the hypoxic induction of the vascular endothelial growth factor (VEGF)
gene is the regulation of the steady-state level of the mRNA. We previously …

Coronary neovascularization may also accompany the early process of vessel wall remodeling,
as observed in hypercholesterolemic swine. 16 In this animal model, neovascularization …

Haptoglobin serves as an antioxidant by virtue of its ability to prevent hemoglobin-driven
oxidative tissue damage. It was recently demonstrated that an allelic polymorphism in the …

Objective— Clinical trials of vitamin E have failed to demonstrate a decrease in cardiovascular
events. However, these studies did not address possible benefit to subgroups with …

Objectives : The goal of this study was to determine if the haptoglobin phenotype was predictive
of cardiovascular disease (CVD) in diabetic mellitus (DM). Background : Cardiovascular …

Haptoglobin is an abundant hemoglobin-binding protein present in the plasma. The function
of haptoglobin is primarily to determine the fate of hemoglobin released from red blood cells …

A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb
complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb …