BAFF (B cell-activating factor belonging to the TNF family) is a cell survival and maturation
factor for B cells, and overproduction of BAFF is associated with systemic autoimmune disease…

OBJECTIVE Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the pathogenesis
of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) mouse strain. …

In an effort to develop more effective treatments for inflammatory diseases, immunologists
have targeted numerous molecular pathways, but with limited success. Notable exceptions are …

B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B cell
maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in the …

Obesity is a major predisposing factor for the development of type 2 diabetes (T2D) and is
an escalating public health issue around the world. The transition from obesity to T2D is …

CD8+ T cells are fundamental for immune-mediated clearance of viral infections and contribute
to immune pathology in autoimmune diseases such as type 1 diabetes. To execute these …

Zbtb20 is a member of the POK family of proteins, which function primarily as transcriptional
repressors via interactions mediated by their conserved C 2 H 2 Krüppel type zinc finger …

An important subdivision of effector T cells can be made based on patterns of cytokine
production and functional programs. Type 1 T cells produce IFN-γ and protect against viral …

B cell-activating factor belonging to the TNF family (BAFF, also termed BLyS, TALL-1, zTNF-4,
THANK, and TNFSF13b) has emerged as a cytokine critical for peripheral B cell survival …

B cell‐activating factor belonging to the TNF family (BAFF) and its receptor BAFF‐R play
critical roles in the maturation and survival of conventional peripheral B cells. However, they …