One way to ensure adequate sensitivity for analgesic trials is to test the intervention on patients
who have established pain of moderate to severe intensity. The usual criterion is at least …

Several conditions associated with reduced gastric acid secretion confer an altered risk of
developing a gastric malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to …

Chronic pain is associated with a range of other problems, including disturbed sleep,
depression, anxiety, fatigue, reduced quality of life, and an inability to work or socialise. We …

The aim was to compare the analgesic effectiveness and adverse effect incidence of oral
dextromethorphan (DM) with placebo in patients with neuropathic pain. The first 10-day …

Improved identification of bacterial and viral infections would reduce morbidity from sepsis,
reduce antibiotic overuse, and lower healthcare costs. Here, we develop a generalizable host…

Conventional clinical trials tell us about the average performance of a therapy. While chronic
pain patients may have symptoms in common, and clearly have pain in common, the origin …

We sought to investigate the potential of using a simple global estimation (‘How effective do
you think the treatment was?’) as a measure of efficacy by comparing it with at least 50% …

Introduction Autoimmune chronic atrophic gastritis (CAG) causes hypochlorhydria and
hypergastrinaemia, which can lead to enterochromaffin-like (ECL) cell hyperplasia and gastric …

Background Hypergastrinaemia occasionally indicates the presence of a gastrinoma. However
it is much more commonly associated with various benign causes including proton pump …

Objectives: A systematic review of the analgesic efficacy and adverse effects of single-dose
aspirin compared with placebo in postoperative pain. Design: Published studies were …