Many human diseases occur when the precise regulation of cell growth (cell mass/size) and
proliferation (rates of cell division) is compromised. This review highlights those human …

Amino acid availability is a rate-limiting factor in the regulation of protein synthesis. When
amino acid supplies become restricted, mammalian cells employ homeostatic mechanisms to …

In order for cells to divide in a proficient manner, they must first double their biomass, which
is considered to be the main rate-limiting phase of cell proliferation. Cell growth requires an …

The S/T-protein kinases activated by phosphoinositide 3-kinase (PI3K) regulate a myriad of
cellular processes. Here, we show that an approach using a combination of biochemistry …

Background: Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs through
the loss of heterozygosity of either TSC1 or TSC2, which encode Hamartin or Tuberin, …

Full article: mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1
and 4E-BP1/Eukaryotic Translation Initiation Factor 4E Skip to Main Content Taylor and …

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that occurs
upon mutation of either the TSC1 or TSC2 genes, which encode the protein products hamartin …

Tumors that form as a result of heightened mammalian target of rapamycin (mTOR) signaling
are highly vascularized. This process of angiogenesis is regulated through hypoxia-…

Amino acids positively regulate signaling through the mammalian target of rapamycin (mTOR).
Recent work demonstrated the importance of the tuberous sclerosis protein TSC2 for …

Loss of tuberin, the product of TSC2 gene, increases mammalian target of rapamycin (mTOR)
signaling, promoting cell growth and tumor development. However, in cells expressing …