User profiles for Andrew S. Bell

Andrew S Bell

Exscientia, Imperial College, Pfizer, Myricx, Salvensis
Verified email at exscientia.co.uk
Cited by 3488

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

NK Terrett, AS Bell, D Brown, P Ellis - Bioorganic & medicinal chemistry …, 1996 - Elsevier
5-(2′-Alkoxyphenyl)pyrazolo[4,3-d]pyrimidin-7-ones, and in particular our preferred
compound, sildenafil (VIAGRA TM ), discovered through a rational drug design programme, are …

Influence of climate on malaria transmission depends on daily temperature variation

KP Paaijmans, S Blanford, AS Bell… - Proceedings of the …, 2010 - National Acad Sciences
Malaria transmission is strongly influenced by environmental temperature, but the biological
drivers remain poorly quantified. Most studies analyzing malaria–temperature relations, …

Virulence and competitive ability in genetically diverse malaria infections

…, S Huijben, AR Wargo, AS Bell… - Proceedings of the …, 2005 - National Acad Sciences
Explaining parasite virulence is a great challenge for evolutionary biology. Intuitively,
parasites that depend on their hosts for their survival should be benign to their hosts, yet many …

Within‐host competition in genetically diverse malaria infections: parasite virulence and competitive success

AS Bell, JC De. Roode, D Sim, AF Read - Evolution, 2006 - academic.oup.com
Humans and animals often become coinfected with pathogen strains that differ in virulence.
The ensuing interaction between these strains can, in theory, be a major determinant of the …

Real-time quantitative PCR in parasitology

AS Bell, LC Ranford-Cartwright - TRENDS in Parasitology, 2002 - cell.com
Standard techniques for counting parasites are often time-consuming, difficult and inaccurate,
and occasionally unpleasant. Real-time quantitative polymerase chain reaction has …

Complex effects of temperature on mosquito immune function

CC Murdock, KP Paaijmans, AS Bell… - … of the Royal …, 2012 - royalsocietypublishing.org
Over the last 20 years, ecological immunology has provided much insight into how environmental
factors shape host immunity and host–parasite interactions. Currently, the application …

[BOOK][B] Forum shopping and venue in transnational litigation

AS Bell - 2003 - books.google.com
… by Oxford University Press Inc., New York Š Andrew S. Bell 2003 The moral rights of the
author have been asserted Database right Oxford University Press (maker) First published 2003 …

The role of immune-mediated apparent competition in genetically diverse malaria infections

L Råberg, JC De Roode, AS Bell… - The American …, 2006 - journals.uchicago.edu
Competitive interactions between coinfecting genotypes of the same pathogen can impose
selection on virulence, but the direction of this selection depends on the mechanisms behind …

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

…, ML Janas, A Galloway, SE Bell, S Andrews… - Nature …, 2010 - nature.com
ZFP36L1 and ZFP36L2 are RNA-binding proteins (RBPs) that interact with AU-rich
elements in the 3′ untranslated region of mRNA, which leads to mRNA degradation and …

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

A Mousnier, AS Bell, DP Swieboda… - Nature …, 2018 - nature.com
Rhinoviruses (RVs) are the pathogens most often responsible for the common cold, and are
a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and …