Gain-of-function IDH mutations are initiating events that define major clinical and prognostic
classes of gliomas 1 , 2 . Mutant IDH protein produces a new onco-metabolite, 2-…

Although human tumours are shaped by the genetic evolution of cancer cells, evidence also
suggests that they display hierarchies related to developmental pathways and epigenetic …

INTRODUCTION Tumor fitness, evolution, and resistance to therapy are governed by
selection of malignant cells with specific genotypes, by expression programs related to cellular …

Stem cells are controlled, in part, by genetic pathways frequently dysregulated during
human tumorigenesis. Either stimulation of Wnt/β-catenin signalling or overexpression of …

Telomerase is a ribonucleoprotein (RNP) complex that synthesizes telomere repeats in
tissue progenitor cells and cancer cells. Active human telomerase consists of at least three …

Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by
stem-like cancer cells refractory to existing therapies. Understanding the molecular …

Telomerase is a multisubunit ribonucleoprotein (RNP) complex that adds telomere repeats
to the ends of chromosomes. Three essential telomerase components have been identified …

Telomerase serves a critical role in stem cell function and tissue homeostasis. This role
depends on its ability to synthesize telomere repeats in a manner dependent on the reverse …

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal
bodies, and telomerase is thought to be recruited to telomeres through interactions with …

Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis
congenita and during human aging. Telomerase depends upon a complex pathway for enzyme …