Genomic stability is critical for the clinical use of human embryonic and induced pluripotent
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …

The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …

Circulating proteins are vital in human health and disease and are frequently used as
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we …

Background Neuroimaging studies have shown structural alterations in several brain regions
in children and adults with attention deficit hyperactivity disorder (ADHD). Through the …

Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Several lines of evidence suggest that genome-wide association studies (GWASs) have the
potential to explain more of the "missing heritability" of common complex phenotypes. …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …

Importance Individuals with mental disorders often develop comorbidity over time. Past
studies of comorbidity have often restricted analyses to a subset of disorders and few studies …

Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost
importance. Although genetic studies have identified AD-associated SNPs in APOE and …