User profiles for Andrew T. McGuire
Andrew McGuireAssistant Professor, Vaccine and Infectious Disease Division Verified email at fredhutch.org Cited by 16210 |
[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…
mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
raised concerns about resistance to neutralizing antibodies elicited by previous infection or …
raised concerns about resistance to neutralizing antibodies elicited by previous infection or …
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
…, CL Leung, J Liu, Y Lu, A MacCamy, AT McGuire… - Science, 2021 - science.org
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …
[PDF][PDF] Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation
Antibody responses develop following SARS-CoV-2 infection, but little is known about their
epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We …
epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We …
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
AT McGuire, S Hoot, AM Dreyer, A Lippy… - Journal of Experimental …, 2013 - rupress.org
Broadly neutralizing antibodies (bnAbs) against HIV are believed to be a critical component
of the protective responses elicited by an effective HIV vaccine. Neutralizing antibodies …
of the protective responses elicited by an effective HIV vaccine. Neutralizing antibodies …
[PDF][PDF] A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses
…, C Morrisseau, P Arlotto, L Stamatatos, AT McGuire… - Cell host & …, 2021 - cell.com
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two
doses administered 3 weeks apart, some public health authorities are spacing these doses, …
doses administered 3 weeks apart, some public health authorities are spacing these doses, …
[HTML][HTML] Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation
…, AB Stuart, J Feng, MS Suthar, AT McGuire… - Nature …, 2020 - nature.com
SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we
determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, …
determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, …
[PDF][PDF] Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice
A subset of individuals infected with HIV-1 develops broadly neutralizing antibodies (bNAbs)
that can prevent infection, but it has not yet been possible to elicit these antibodies by …
that can prevent infection, but it has not yet been possible to elicit these antibodies by …
[PDF][PDF] Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …
[PDF][PDF] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …