User profiles for Andrew T. McGuire

Andrew McGuire

Assistant Professor, Vaccine and Infectious Disease Division
Verified email at fredhutch.org
Cited by 16210

[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein

AC Walls, YJ Park, MA Tortorici, A Wall, AT McGuire… - Cell, 2020 - cell.com
The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies…

mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

…, KW Cohen, Z Moodie, MJ McElrath, AT McGuire - Science, 2021 - science.org
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
raised concerns about resistance to neutralizing antibodies elicited by previous infection or …

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

…, CL Leung, J Liu, Y Lu, A MacCamy, AT McGuire… - Science, 2021 - science.org
Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …

[PDF][PDF] Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation

…, JA Englund, HY Chu, M Pancera, AT McGuire… - Immunity, 2020 - cell.com
Antibody responses develop following SARS-CoV-2 infection, but little is known about their
epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We …

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

AT McGuire, S Hoot, AM Dreyer, A Lippy… - Journal of Experimental …, 2013 - rupress.org
Broadly neutralizing antibodies (bnAbs) against HIV are believed to be a critical component
of the protective responses elicited by an effective HIV vaccine. Neutralizing antibodies …

[PDF][PDF] A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

…, C Morrisseau, P Arlotto, L Stamatatos, AT McGuire… - Cell host & …, 2021 - cell.com
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two
doses administered 3 weeks apart, some public health authorities are spacing these doses, …

[HTML][HTML] Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

…, AB Stuart, J Feng, MS Suthar, AT McGuire… - Nature …, 2020 - nature.com
SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we
determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30, …

[PDF][PDF] Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice

…, NT Freund, AD Gitlin, AT McGuire, DW Kulp, T Oliveira… - Cell, 2015 - cell.com
A subset of individuals infected with HIV-1 develops broadly neutralizing antibodies (bNAbs)
that can prevent infection, but it has not yet been possible to elicit these antibodies by …

[PDF][PDF] Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

…, EA Bruce, DE Kaufmann, L Stamatatos, AT McGuire… - Immunity, 2021 - cell.com
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …

[PDF][PDF] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

…, J Richard, F Zhou, L Stamatatos, AT McGuire… - Cell reports, 2022 - cell.com
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …