Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type
2 diabetes 1 , 2 . Previous metagenomic studies have described the characteristics of gut …

Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian
genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we …

Single-cell transcriptomic profiling is a powerful tool to explore cellular heterogeneity. However,
most of these methods focus on the 3′-end of polyadenylated transcripts and provide …

The human body consists of 37 trillion single cells represented by over 50 organs that are
stitched together to make us who we are, yet we still have very little understanding about the …

Cell culture systems reproducing virus replication can serve as unique models for the discovery
of novel bioactive molecules. Here, using a hepatitis C virus (HCV) cell culture system, …

Regulation of gene expression is a key feature for higher eukaryotes and how chromatin
topology relates to gene activation is an intense area of research. Enhancer–promoter …

Antibody-drug conjugates offers many advantages as a drug delivery platform that allows
for highly specific targeting of cell types and genes. Ideally, testing the efficacy of these …

Mutations in the DFNA5 gene are known to cause autosomal dominant non-syndromic
hearing loss (ADNSHL). To date, five DFNA5 mutations have been reported, all of which were …

Antibody-drug conjugates offers many advantages as a drug delivery platform that allows
for highly specific targeting of cell types and genes. Ideally, testing the efficacy of these …

We propose a new method for finding potential regulatory relationships between pairs of
genes from microarray time series data and apply it to expression data for cell-cyle related …