Chikungunya virus (CHIKV) is a re-emerging, pathogenic Alphavirus transmitted to humans
by Aedes spp. mosquitoes. We have mapped the RNA structure of the 5′ region of the …

A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C
virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (…

Zika virus is a mosquito-borne Flavivirus originally isolated from humans in 1952. Following
its re-emergence in Brazil in 2015, an increase in the number of babies born with …

Chikungunya virus (CHIKV) is a re-emerging, pathogenic alphavirus that is transmitted to
humans by Aedes spp. mosquitoes—causing fever and debilitating joint pain, with frequent …

Discrete RNA secondary and higher-order structures, typically local in extent, play a
fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have …

Nanopore systems have emerged as a leading platform for the analysis of biomolecular
complexes with single-molecule resolution. The conformation of biomolecules, such as RNA, is …

The existence and functional importance of RNA secondary structure in the replication of
positive-stranded RNA viruses is increasingly recognized. We applied several computational …

The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs)
comprised of RNA stem-loop structures located in both the 5′ and 3′ noncoding regions (5′ …

Chikungunya virus (CHIKV) is a re-emerging Alphavirus causing fever, joint pain, skin rash,
arthralgia, and occasionally death. Antiviral therapies and/or effective vaccines are urgently …

The RNA structure and long-range interactions of the SL9266 cis -acting replication element
located within the NS5B coding region of hepatitis C virus (HCV) were determined using …