Wnt signalling is involved in numerous events in animal development 1 , including the
proliferation of stem cells 2 and the specification of the neural crest 3 . Wnt proteins are potentially …

Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all
lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. …

A fundamental question in hematopoietic stem cell (HSC) biology is how self-renewal is
controlled. Here we show that the molecular regulation of two critical elements of self-renewal, …

One of the defining features of the liver is the capacity to maintain a constant size despite
injury. Although the precise molecular signals involved in the maintenance of liver size are not …

Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and higher) are found
in all mammalian species, but the functional significance of this conserved phenomenon …

The molecular identification of adult hepatic stem/progenitor cells has been hampered by
the lack of truly specific markers. To isolate putative adult liver progenitor cells, we used cell …

Murine hepatocytes become polyploid and then undergo ploidy reversal and become
aneuploid in a dynamic process called the ploidy conveyor. Although polyploidization occurs in …

Polyploidy has been described in the liver for over 100 years. The frequency of polyploid
hepatocytes varies by age and species, but up to 90% of mouse hepatocytes and …

Over half of the mature hepatocytes in mice and humans are aneuploid and yet retain full
ability to undergo mitosis. This observation has raised the question of whether this unusual …

The availability of an autologous transplantable auxiliary liver would dramatically affect the
treatment of liver disease. Assembly and function in vivo of a bioengineered human liver …