Zinc-induced aggregation of amyloid-β peptide (Aβ) is a hallmark molecular feature of
Alzheimer's disease. Here we provide direct thermodynamic evidence that elucidates the role of …

Analysis of complex formation between amyloid-β fragments using surface plasmon resonance
biosensing and electrospray mass spectrometry reveals that region 11–14 mediates zinc-…

Aggregation of TDP-43 (transactive response DNA binding protein 43 kDa) is a hallmark of
certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (…

According to the water replacement hypothesis, trehalose stabilizes dry membranes by
preventing the decrease of spacing between membrane lipids under dehydration. In this study, …

A combination of explicit solvent molecular dynamics simulation (30 simulations reaching 4
µs in total), hybrid quantum mechanics/molecular mechanics approach and isothermal …

Zinc-induced aggregation of the amyloid-β peptide (Aβ) is a hallmark molecular feature of
Alzheimer's disease (AD). Recently it was shown that phosphorylation of Aβ at Ser8 promotes …

Transfer RNA is highly modified. Nucleotide 37 of the anticodon loop is represented by various
modified nucleotides. In Escherichia coli, the valine-specific tRNA (cmo 5 UAC) contains …

10.7554/eLife.37373.001 The ubiquitous P-loop fold nucleoside triphosphatases (NTPases)
are typically activated by an arginine or lysine ‘finger’. Some of the apparently ancestral …

Oligonucleotide probes labeled with pyrene pairs that form excimers have a number of
applications in hybridization analysis of nucleic acids. A long excited state lifetime, large Stokes …

Neuronal calcium sensor-1 (NCS-1) protein is abundantly expressed in the central nervous
system and retinal neurons, where it regulates many vital processes such as synaptic …