Minimally invasive classification of paediatric solid tumours using reduced representation bisulphite sequencing of cell-free DNA: a proof-of-principle study

R Van Paemel, A De Koker, C Vandeputte… - Epigenetics, 2021 - Taylor & Francis
In the clinical management of paediatric solid tumours, histological examination of tumour
tissue obtained by a biopsy remains the gold standard to establish a conclusive pathological …

GENType: all-in-one preimplantation genetic testing by pedigree haplotyping and copy number profiling suitable for third-party reproduction

…, L Raman, M Baetens, A De Koker… - Human …, 2022 - academic.oup.com
STUDY QUESTION Is it possible to develop a comprehensive pipeline for all-in-one preimplantation
genetic testing (PGT), also suitable for parents-only haplotyping and, for the first time…

[HTML][HTML] The feasibility of using liquid biopsies as a complementary assay for copy number aberration profiling in routinely collected paediatric cancer patient samples

…, M Van Der Linden, J De Wilde, A De Koker… - European Journal of …, 2022 - Elsevier
Background Paediatric tumours are often characterised by the presence of recurrent DNA
copy number alterations (CNAs). These DNA copy number profiles, obtained from a tissue …

Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome

R Van Paemel, A De Koker, C Caggiano, A Morlion… - Epigenetics, 2021 - Taylor & Francis
The methylation pattern of cfDNA, isolated from liquid biopsies, is gaining substantial interest
for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood …

Capturing the 'ome': the expanding molecular toolbox for RNA and DNA library construction

M Boone, A De Koker, N Callewaert - Nucleic Acids Research, 2018 - academic.oup.com
All sequencing experiments and most functional genomics screens rely on the generation of
libraries to comprehensively capture pools of targeted sequences. In the past decade …

A versatile method for circulating cell-free DNA methylome profiling by reduced representation bisulfite sequencing

A De Koker, R Van Paemel, B De Wilde, K De Preter… - bioRxiv, 2019 - biorxiv.org
The methylation profile of circulating cell-free DNA (cfDNA) in blood can be exploited to
detect and diagnose cancer and other tissue pathologies and is therefore of great diagnostic …

Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA: a proof-of-principle study

R Van Paemel, A De Koker, C Vandeputte… - biorxiv, 2019 - biorxiv.org
In the clinical management of pediatric solid tumors, histological examination of tumor tissue
obtained by a biopsy remains the gold standard to establish a conclusive pathological …

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

…, J Van Thorre, R Van Paemel, A De Koker… - 19th Annual BeSHG …, 2019 - biblio.ugent.be
… Vandeputte, Charlotte, Jolien Van Thorre, Ruben Van Paemel, Andries De Koker, Leen
Willems, Jo Van Dorpe, Malaïka Van der Linden, et al. 2019. “Shallow Whole Genome …

Successful copy number alteration profiling using circulating cell-free tumor DNA as a non-invasive alternative for tissue biopsies in pediatric cancer patients

…, J Van Thorre, R Van Paemel, A De Koker… - 3de Nederlandse cell …, 2019 - biblio.ugent.be
… Vandeputte, Charlotte, Jolien Van Thorre, Ruben Van Paemel, Andries De Koker, Leen
Willems, Jo Van Dorpe, Malaïka Van der Linden, et al. 2019. “Successful Copy Number Alteration …

[PDF][PDF] HEK293 GlycoDelete: optimalisatie door vergelijking van verschillende endoglycosidasen

A DE KOKER - scriptiebank.be
Dit document en de informatie die het omvat, worden voorgesteld in confidentialiteit, met als
enig doel de evaluatie van de Masterproef van Andries De Koker, en mogen niet onthuld …