Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a
critical step regulating gene expression in multicellular organisms. The transition of Pol II into …

The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II (RNAPII)
transcription termination and transcript decay. Despite its essential nature, the …

DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms
of which remain ill defined. Here, we show that following genotoxic stress, the RNA-binding …

Viral diseases remain serious threats to public health because of the shortage of effective
means of control. To combat the surge of viral diseases, new treatments are urgently needed. …

Influenza A viruses ( IAV s) remain serious threats to public health because of the shortage
of effective means of control. Developing more effective virus control modalities requires …

Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded
(ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we …

Positive transcription elongation factor b (P-TEFb) is the crucial player in RNA polymerase II
(Pol II) pause release that has emerged as a promising target in cancer. Because single-…

Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA polymerase
II (RNAPII)-derived transcripts. Yet, our current understanding of this process in vivo …

Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected
or RNA/DNA-transfected cells provides rationale for investigating these apoptotic …

1 ABSTRACT DNA damage response (DDR) is a cascade of events within the cells, which
is initiated by DNA lesions and results in DNA repair and cell survival. Alternatively, DDR …