User profiles for Andromachi Pouikli
 | Andromachi PouikliPostdoctoral Researcher, CECAD - University of Cologne Verified email at uk-koeln.de Cited by 192 |
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19
Innate immunity triggers responsible for viral control or hyperinflammation in COVID‐19 are
largely unknown. Here we show that the SARS‐CoV‐2 spike protein (S‐protein) primes …
largely unknown. Here we show that the SARS‐CoV‐2 spike protein (S‐protein) primes …
[HTML][HTML] Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells
Aging is accompanied by a general decline in the function of many cellular pathways.
However, whether these are causally or functionally interconnected remains elusive. Here, we …
However, whether these are causally or functionally interconnected remains elusive. Here, we …
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication
A Pouikli, M Maleszewska, S Parekh, M Yang… - The EMBO …, 2022 - embopress.org
Bone‐derived mesenchymal stem cells (MSCs) reside in a hypoxic niche that maintains their
differentiation potential. While hypoxia (low oxygen concentration) was reported to critically …
differentiation potential. While hypoxia (low oxygen concentration) was reported to critically …
Metabolism and chromatin: A dynamic duo that regulates development and ageing: Elucidating the metabolism‐chromatin axis in bone‐marrow mesenchymal stem …
Bone‐marrow mesenchymal stem cell (BM‐MSC) proliferation and lineage commitment are
under the coordinated control of metabolism and epigenetics; the MSC niche contains low …
under the coordinated control of metabolism and epigenetics; the MSC niche contains low …
Epigenetic alterations in stem cell ageing—a promising target for age-reversing interventions?
Ageing is accompanied by loss of tissue integrity and organismal homeostasis partly due to
decline in stem cell function. The age-associated decrease in stem cell abundance and …
decline in stem cell function. The age-associated decrease in stem cell abundance and …
N1-acetylspermidine is a determinant of hair follicle stem cell fate
Stem cell differentiation is accompanied by increased mRNA translation. The rate of protein
biosynthesis is influenced by the polyamines putrescine, spermidine and spermine, which …
biosynthesis is influenced by the polyamines putrescine, spermidine and spermine, which …
[PDF][PDF] FOXA2 controls the anti-oxidant response in FH-deficient cells
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by
inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of …
inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of …
Metabolic control of antitumor immunity
The metabolism of cancer cells adapts to meet an increased need for the energy, biosynthesis,
and antioxidants required for proliferation, tumor growth, and metastasis ( 1 ). Yet, …
and antioxidants required for proliferation, tumor growth, and metastasis ( 1 ). Yet, …
Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal stem cells upon ageing
Ageing is accompanied by a general decline in the function of many cellular pathways, with
metabolic alterations, epigenetic modifications, and stem cell exhaustion representing three …
metabolic alterations, epigenetic modifications, and stem cell exhaustion representing three …
Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate
Stem cell differentiation is accompanied by an increase in mRNA translation. The rate of
protein biosynthesis is influenced by the polyamines putrescine, spermidine, and spermine that …
protein biosynthesis is influenced by the polyamines putrescine, spermidine, and spermine that …