Highly recommended by JASA, Technometrics, and other leading statistical journals, the first
two editions of this bestseller showed how to easily perform complex linear mixed model (…

In Chap.10, we presented linear models (LMs) models with fixed effects for correlated data.
They are examples of population-averaged models, because their mean-structure …

Importance Cognitive decline is a major cause of disability in stroke survivors. The magnitude
of survivors’ cognitive changes after stroke is uncertain. Objective To measure changes in …

Importance Sex differences in dementia risk are unclear, but some studies have found greater
risk for women. Objective To determine associations between sex and cognitive decline in …

OBJECTIVE We previously described a cross-sectional association between serum uric acid
and reduced glomerular filtration rate (GFR) in nonproteinuric patients with type 1 diabetes. …

Background Higher serum urate levels are associated with an increased risk of diabetic kidney
disease. Lowering of the serum urate level with allopurinol may slow the decrease in the …

The main difficulty in parametric analysis of longitudinal data lies in specifying covariance
structure. Several covariance structures, which usually reflect one series of measurements …

Small body size has been associated with long life span in four stocks of mutant dwarf mice,
and in two varieties of dietary restriction in rodents. In this study, small body size at ages 2–…

Background. Studies of Clostridium difficile outbreaks suggested that certain ribotypes (eg,
027 and 078) cause more severe disease than other ribotypes. A growing number of studies …

Influenza A viral infection begins by hemagglutinin glycoproteins on the viral envelope
binding to cell membrane sialic acid (SA). Free SA monomers cannot block hemagglutinin …