User profiles for Andrzej J Rutkowski
 | Andrzej J. RutkowskiLead Scientist Verified email at md.catapult.org.uk Cited by 1299 |
Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities
…, AJ Rutkowski, J Cisowski… - Antioxidants & redox …, 2008 - liebertpub.com
Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin,
has been recognized as playing a crucial role in cellular defense against stressful conditions, …
has been recognized as playing a crucial role in cellular defense against stressful conditions, …
[HTML][HTML] Widespread disruption of host transcription termination in HSV-1 infection
AJ Rutkowski, F Erhard, A L'Hernault, T Bonfert… - Nature …, 2015 - nature.com
Herpes simplex virus 1 (HSV-1) is an important human pathogen and a paradigm for virus-induced
host shut-off. Here we show that global changes in transcription and RNA processing …
host shut-off. Here we show that global changes in transcription and RNA processing …
Metabolic labeling of newly transcribed RNA for high resolution gene expression profiling of RNA synthesis, processing and decay in cell culture
B Rädle, AJ Rutkowski, Z Ruzsics, CC Friedel… - JoVE (Journal of …, 2013 - jove.com
The development of whole-transcriptome microarrays and next-generation sequencing has
revolutionized our understanding of the complexity of cellular gene expression. Along with a …
revolutionized our understanding of the complexity of cellular gene expression. Along with a …
[HTML][HTML] Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA
V Rowlands, AJ Rutkowski, E Meuser, TH Carr… - Scientific Reports, 2019 - nature.com
Liquid biopsies offer the potential to monitor cancer response and resistance to therapeutics
in near real-time. However, the plasma cell free DNA (cfDNA) level can be low and the …
in near real-time. However, the plasma cell free DNA (cfDNA) level can be low and the …
[HTML][HTML] Integrative functional genomics decodes herpes simplex virus 1
The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been
intensively studied for decades. Here, we unravel the complete viral transcriptome and …
intensively studied for decades. Here, we unravel the complete viral transcriptome and …
[HTML][HTML] HSV-1-induced disruption of transcription termination resembles a cellular stress response but selectively increases chromatin accessibility downstream of …
T Hennig, M Michalski, AJ Rutkowski, L Djakovic… - PLoS …, 2018 - journals.plos.org
Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination
(DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, …
(DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, …
Dissecting herpes simplex virus 1-induced host shutoff at the RNA level
…, AW Whisnant, L Djakovic, AJ Rutkowski… - Journal of …, 2021 - Am Soc Microbiol
Herpes simplex virus 1 (HSV-1) induces a profound host shutoff during lytic infection. The
virion host shutoff (vhs) protein plays a key role in this process by efficiently cleaving host and …
virion host shutoff (vhs) protein plays a key role in this process by efficiently cleaving host and …
[HTML][HTML] CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells
TD Southgate, OJ McGinn, FV Castro, AJ Rutkowski… - PloS one, 2010 - journals.plos.org
5T4 oncofetal molecules are highly expressed during development and upregulated in cancer
while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a …
while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a …
5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic …
…, OJ McGinn, S Krishnan, G Marinov, J Li, AJ Rutkowski… - Leukemia, 2012 - nature.com
Although the overall prognosis in childhood acute lymphoblastic leukemia (ALL) is good,
outcome after relapse is poor. Recurrence is frequently characterized by the occurrence of …
outcome after relapse is poor. Recurrence is frequently characterized by the occurrence of …
Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis
Interferons (IFN) play a pivotal role in innate immunity, orchestrating a cell-intrinsic anti-pathogenic
state and stimulating adaptive immune responses. The complex interplay between …
state and stimulating adaptive immune responses. The complex interplay between …