Cytosine base editors and adenine base editors (ABEs) can correct point mutations
predictably and independent of Cas9-induced double-stranded DNA breaks (which causes …

Leber congenital amaurosis (LCA) is the most common cause of inherited retinal degeneration
in children. LCA patients with RPE65 mutations show accelerated cone photoreceptor …

To combat retinal degeneration, healthy fetal retinal sheets have been successfully transplanted
into both rodent models and humans, with synaptic connectivity between transplant and …

Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses
intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with …

Purpose.: Little is known about the physiological mechanisms underlying the reported
therapeutic effects of transorbital alternating current stimulation (ACS) in vision restoration, or the …

Mutations in many visual cycle enzymes in photoreceptors and retinal pigment epithelium (RPE)
cells can lead to the chronic accumulation of toxic retinoid byproducts, which poison …

Inherited retinal degenerative diseases are a prominent cause of blindness. Although mutations
causing death of photoreceptors are mostly known, the pathophysiology downstream in …

Primary sensory areas of the mammalian neocortex have a remarkable degree of plasticity,
allowing neural circuits to adapt to dynamic environments. However, little is known about the …

The pulvinar is a higher-order thalamic relay and a central component of the extrageniculate
visual pathway, with input from the superior colliculus and visual cortex and output to all of …

The extrageniculate visual pathway, which carries visual information from the retina through
the superficial layers of the superior colliculus and the pulvinar, is poorly understood. The …