This protocol is an extension to: Nat. Protoc.1, 1552–1558 (2006); doi:10.1038/nprot.2006.276;
published online 9 November 2006 This article describes how to reliably electroporate …

The PCDH19 gene (Xp22.1) encodes the cell-adhesion protein protocadherin-19 (PCDH19)
and is responsible for a neurodevelopmental pathology characterized by female-limited …

In the developing cerebral cortex, how progenitors that seemingly display limited diversity
end up producing a vast array of neurons remains a puzzling question. The prevailing model …

The development of functional synapses is a sequential process preserved across many
brain areas. Here, we show that glutamatergic postsynaptic currents anticipated GABAergic …

Mutations and deletions of the interleukin-1 receptor accessory protein like 1 (IL1RAPL1)
gene, located on the X chromosome, are associated with intellectual disability (ID) and autism …

Ribosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons.
The axonal localization of translational machinery allows new proteins to be rapidly and …

Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations
in genes encoding proteins involved in centrosomal and chromosomal dynamics during …

Accurate and timely expression of specific genes guarantees the healthy development and
function of the brain. Indeed, variations in the correct amount or timing of gene expression …

Changes in transcriptional regulation through cis-regulatory elements are thought to drive
brain evolution. However, how this impacts the identity of primate cortical neurons is still …

Alteration of centrosome function and dynamics results in major defects during chromosome
segregation and is associated with primary autosomal microcephaly (MCPH). Despite the …