Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise
the outcomes of a cohort of patients with cancer and COVID-19 and identify potential …

Triple-negative breast cancer (TNBC) has poor prognostic outcome compared with other
types of breast cancer. The molecular and cellular mechanisms underlying TNBC pathology …

Crosstalk between tumor cells and other cells within the tumor microenvironment (TME) plays
a crucial role in tumor progression, metastases, and therapy resistance. We present iTALK, …

Sensitivity to Her2-directed therapies is complex and involves expression not only of Her2
but also of other epidermal growth factor receptor (EGFR) family members, their ligands, and …

During the clonal expansion of cancer from an ancestral cell with an initiating oncogenic
mutation to symptomatic neoplasm, the occurrence of somatic mutations (both driver and …

Ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (iGluRs)
mediate the majority of excitatory synaptic transmission in the CNS and are essential for …

Purpose: Despite the prognostic importance of immune infiltrate in colorectal cancer,
immunotherapy has demonstrated limited clinical activity in refractory metastatic proficient mismatch…

Blastoid and pleomorphic mantle cell lymphomas (MCLs) are variants of aggressive
histology MCL (AH-MCL). AH-MCL can arise de novo (AH-DN) or transform from prior classic …

Clonal hematopoiesis (CH) is associated with older age and an increased risk of myeloid
malignancies and cardiovascular complications. We analyzed donor DNA samples in patients …

Due to widespread adoption of screening mammography, there has been a significant increase
in new diagnoses of ductal carcinoma in situ (DCIS). However, DCIS prognosis remains …