Histone acetylation is important in chromatin remodelling and gene activation 1 , 2 , 3 , 4 .
Nearly all known histone-acetyltransferase (HAT)-associated transcriptional co-activators …

The precise mechanistic relationship between gene activation and repression events is a
central question in mammalian organogenesis, as exemplified by the evolutionarily conserved …

FokI is a type IIs restriction endonuclease comprised of a DNA recognition domain and a
catalytic domain. The structural similarity of the FokI catalytic domain to the type II restriction …

… Harrison and Aneel K. Aggarwal1 … Kaptein and K. Wiithrich for sending unpublished
coordinates and manuscripts prior to publication; BW Matthews and GB Koudelka for …

The repressors of temperate bacteriophages such as 434 and lambda control transcription
by binding to a set of DNA operator sites. The different affinity of repressor for each of these …

The family of interferon regulatory factor (IRF) transcription factors is important in the
regulation of interferons in response to infection by virus and in the regulation of interferon-inducible …

While reversible histone modifications are linked to an ever-expanding range of biological
functions 1 , 2 , 3 , 4 , 5 , the demethylases for histone H4 lysine 20 and their potential …

Distal enhancers characterized by the H3K4me 1 mark play critical roles in developmental
and transcriptional programs. However, potential roles of specific distal regulatory elements in …

DNA polymerase η is unique among eukaryotic polymerases in its proficient ability to
replicate through a variety of distorting DNA lesions. We report here the crystal structure of the …

The recognition of specific DNA-binding sites by transcription factors is a critical yet poorly
understood step in the control of gene expression. Members of the Hox family of transcription …