User profiles for Aneesh Chandran

Aneesh chandran

- Verified email at ucl.ac.uk - Cited by 1520

Aneesh Chandran

- Verified email at kannuruniv.ac.in - Cited by 437

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

…, G Captur, O Carr, N Champion, C Chan, A Chandran… - Science, 2022 - science.org
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

[HTML][HTML] Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

…, MO Diniz, NM Schmidt, OE Amin, A Chandran… - Nature, 2022 - nature.com
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
do not necessarily develop PCR or antibody positivity, suggesting that some …

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

…, M Jones, WYJ Lee, J Rosenheim, A Chandran… - Science …, 2020 - science.org
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2
is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody …

Groove binding mechanism of ionic liquids: a key factor in long-term stability of DNA in hydrated ionic liquids?

A Chandran, D Ghoshdastidar… - Journal of the American …, 2012 - ACS Publications
Nucleic acid sample storage is of paramount importance in biotechnology and forensic
sciences. Very recently, hydrated ionic liquids (ILs) have been identified as ideal media for long-…

[HTML][HTML] Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy …

RK Gupta, J Rosenheim, LC Bell, A Chandran… - The Lancet …, 2021 - thelancet.com
Background We hypothesised that host-response biomarkers of viral infections might
contribute to early identification of individuals infected with SARS-CoV-2, which is critical to …

[PDF][PDF] Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections

A Chandran, J Rosenheim, G Nageswaran… - Cell Reports …, 2022 - cell.com
Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of
protective immunity to future variants, but we lack insights into immune responses before or at …

[HTML][HTML] Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an …

…, HM Martineau, M Noursadeghi, A Chandran… - The Lancet …, 2021 - thelancet.com
Background Haematopoietic stem cells expressing the CD34 surface marker have been
posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis …

[HTML][HTML] Mycobacterium tuberculosis Infection Induces HDAC1-Mediated Suppression of IL-12B Gene Expression in Macrophages

A Chandran, C Antony, L Jose, S Mundayoor… - Frontiers in cellular …, 2015 - frontiersin.org
Downregulation of host gene expression is one of the many strategies employed by
intracellular pathogens such as Mycobacterium tuberculosis (MTB) to survive inside the …

Hypothetical protein Rv3423.1 of Mycobacterium tuberculosis is a histone acetyltransferase

…, R Bhagavat, RL Gomez, A Chandran… - The FEBS …, 2016 - Wiley Online Library
We isolated an 8 kDa mycobacterial hypothetical protein, Rv3423.1, from the chromatin of
human macrophages infected with Mycobacterium tuberculosis H37Rv. Bioinformatics …

Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease

…, CT Turner, J Rosenheim, A Chandran… - Science translational …, 2021 - science.org
Host immune responses at the site of Mycobacterium tuberculosis infection can mediate
pathogenesis of tuberculosis (TB) and onward transmission of infection. We hypothesized that …