How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …

During neurogenesis, neural stem/progenitor cells (NPCs) undergo an irreversible fate transition
to become neurons. The Notch pathway is important for this process, and repression of …

Virus entry is a major step in which host‐cell lipids can play an essential role. In this report,
we investigated the importance of sphingolipids in hepatitis C virus (HCV) entry. For this …

The study of human cortical development has major implications for brain evolution and
diseases but has remained elusive due to paucity of experimental models. Here we found that …

Disrupted differentiation during development can lead to oncogenesis, but the underlying
mechanisms remain poorly understood. Here we identify BCL6, a transcriptional repressor and …

The cerebral cortex underwent rapid expansion and increased complexity during recent
hominid evolution. Gene duplications constitute a major evolutionary force, but their impact on …

The developmental mechanisms through which the cerebral cortex increased in size and
complexity during primate evolution are essentially unknown. To uncover genetic networks …

The transplantation of pluripotent stem-cell-derived neurons constitutes a promising avenue
for the treatment of several brain diseases. However, their potential for the repair of the …

Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or
impairing β cell function. Understanding the genetic basis of rare diabetes subtypes …

The primary cilium is a central signaling component during embryonic development. Here
we focus on CROCCP2, a hominid-specific gene duplicate from ciliary rootlet coiled coil (…