The increased concentration of platelets within platelet-rich plasma (PRP) provides a vehicle
to deliver supra-physiologic concentrations of growth factors to an injury site, possibly …

Calcium phosphates (CaPs) are among the most utilized synthetic biomaterials for bone
regeneration, largely owing to their established osteoconductive and osteoinductive properties. …

It is well-established that cyclic, but not static, mechanical loading has anabolic effects on
bone. However, the function describing the relationship between the loading frequency and …

On activation, platelets secrete an array of growth factors that contribute to bone regeneration.
Combining platelet-rich plasma (PRP) with bone graft substitutes has the potential to …

Purpose of Review Connecting organ-scale loads to cellular signals in their local in vivo
environment is a current challenge in the field of bone (re)modelling. Understanding this critical …

Appropriate well-characterized bone defect animal models remain essential for preclinical
research. This pilot study demonstrates a relevant animal model for cancellous bone defect …

Bone healing requires two critical mechanisms, angiogenesis and osteogenesis. In order to
improve bone graft substitutes, both mechanisms should be addressed simultaneously. …

The incorporation of bioinorganics into synthetic biomaterials is a promising approach to
improve the biological performance of bone graft substitutes, while still retaining their synthetic …

Methods to repair bone defects arising from trauma, resection, or disease, continue to be
sought after. Cyclic mechanical loading is well established to influence bone (re)modelling …

It is well established that cyclic, but not static, mechanical loading has anabolic effects on bone.
However, the function describing the relationship between the loading frequency and the …