Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG)
generated in the different cellular compartments in various physiological processes. DAG …

Hyperreactive platelets are commonly observed in diabetic patients indicating a potential
link between glucose homeostasis and platelet reactivity. This raises the possibility that …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that targets LDL
receptors (LDLRs) for degradation in liver. Blocking the interaction of PCSK9 with the LDLR …

Hepatic activation of protein kinase C (PKC) isoforms by diacylglycerol (DAG) promotes
insulin resistance and contributes to the development of type 2 diabetes (T2D). The closely …

Nutrient overload in combination with decreased energy dissipation promotes obesity and
diabetes. Obesity results in a hormonal imbalance, which among others activates G protein‐…

Lipids are the most energy‐dense components of the diet, and their overconsumption promotes
obesity and diabetes. Dietary fat content has been linked to the lipid processing activity …

Obesity-induced diabetes affects> 400 million people worldwide. Uncontrolled lipolysis (free
fatty acid release from adipocytes) can contribute to diabetes and obesity. To identify future …

Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins
have been shown to be physically associated with lipid droplets and govern their function. …

Kinases represent one of the largest druggable families of proteins. Importantly, many kinases
are aberrantly activated/de-activated in multiple organs during obesity, which contributes …

Members of the protein kinase D (PKD) family (PKD1, 2, and 3) integrate hormonal and
nutritional inputs to regulate complex cellular metabolism. Despite the fact that a number of …