Parkinson’s disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy …

Converging evidence from genetic, pathological and experimental studies have
increasingly suggested an important role for autophagy impairment in Parkinson’s Disease (PD). …

G M1 -ganglioside (G M1 ) is a major sialoglycolipid of neuronal membranes that, among
other functions, modulates calcium homeostasis. Excessive accumulation of G M1 due to …

Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of
Parkinson’s disease (PD). To elucidate molecular mechanisms underlying neuronal dysfunction …

Background Most patients with Parkinson's disease, Parkinson's disease dementia, and
dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of …

Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase),
are the most common known genetic risk factor for Parkinson’s disease (PD) and dementia …

Bone marrow cells (BMCs) could correct some pathologic conditions of the central nervous
system (CNS) if these cells would effectively repopulate the brain. One such condition is G …

The molecular mechanisms underlying caudal-to-rostral progression of Lewy body pathology
in Parkinson’s disease remain poorly understood. Here, we identified transcriptomic …

Growing evidence suggests a crucial role of neuroinflammation in the pathophysiology of
Parkinson’s disease (PD). Neuroinflammation is linked to the accumulation and aggregation of …

Parkinson’s disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy …