Microglia, the resident immune cells of the mammalian central nervous system (CNS), play
a pivotal role in both physiological and pathological conditions such as the restoration of …

Aim The aim of this study was to assess the diagnostic approach to microcephaly in childhood
and to identify the prevalence of the various underlying causes/disease entities. Method …

The hypomyelinating leukodystrophies X-linked Pelizaeus-Merzbacher disease (PMD) and
Pelizaeus-Merzbacher–like disease (PMLD) are characterized by nystagmus, progressive …

The developing brain is particularly vulnerable to reactive oxygen and reactive nitrogen
species–mediated damage because of its high concentrations of unsaturated fatty acids, high …

… Author links open overlay panel Angela M. Kaindl a b c d 1 , Sandrine Passemard a b e f
1 , Pavan Kumar g , Nadine Kraemer c d , Lina Issa c d , Angelika Zwirner c d , Benedicte …

Glutamate antagonists limit the growth of human cancers in vitro. The mechanism of
anticancer action of NMDA antagonists is not known, however. In this article, we report that the …

10.7554/eLife.16078.001 Mitochondriopathies often present clinically as multisystemic
disorders of primarily high-energy consuming organs. Assembly, turnover, and surveillance of …

The impact that next-generation sequencing technology (NGS) is having on many aspects of
molecular and cell biology, is becoming increasingly apparent. One of the most noticeable …

Objective: Activated microglia play a central role in the inflammatory and excitotoxic component
of various acute and chronic neurological disorders. However, the mechanisms leading …

Golgi staining remains a key method to study neuronal morphology in vivo. Since most
protocols delineating modifications of the original staining method lack details on critical steps, …