Beneficial microbes and probiotics show promise for the treatment of pediatric gastrointestinal
diseases. However, basic mechanisms of probiosis are not well understood, and most …

Probiotics and commensal intestinal microbes suppress mammalian cytokine production and
intestinal inflammation in various experimental model systems. Limited information exists …

Background Numerous reports have documented bacteria in the placental membranes and
basal plate decidua in the absence of immunopathology using histologic techniques. …

Microbiome-mediated suppression of carcinogenesis may open new avenues for identification
of therapeutic targets and prevention strategies in oncology. Histidine decarboxylase (…

Accumulating studies have defined a role for the intestinal microbiota in modulation of host
behavior. Research using gnotobiotic mice emphasizes that early microbial colonization with …

Objectives: Beneficial microbes and probiotics are promising agents for the prevention and
treatment of enteric and diarrheal diseases in children; however, little is known about their in …

… A major limitation of the present study was the failure to collect urine in all the mice in the 3
groups due to a miscommunication with the animal care staff. Previously, we have shown that …

Fanconi anemia (FA) is an inherited bone marrow failure disorder associated with a high
incidence of leukemia and solid tumors. Bone marrow transplantation is currently the only …

Many genetic and acquired liver disorders are amenable to gene and/or cell therapy.
However, the efficiencies of cell engraftment and stable genetic modification are low and often …

Eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD) have similar
clinical presentations. The immunoregulatory mechanisms involved in both diseases are not …