β-amyloid monomers are neuroprotective
…, G Molinaro, G Pappalardo, A Messina… - Journal of …, 2009 - Soc Neuroscience
The 42-aa-long β-amyloid protein—Aβ 1-42 —is thought to play a central role in the pathogenesis
of Alzheimer's disease (AD) ( Walsh and Selkoe, 2007 ). Data from AD brain ( Shankar …
of Alzheimer's disease (AD) ( Walsh and Selkoe, 2007 ). Data from AD brain ( Shankar …
[HTML][HTML] VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria
Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common
channeling properties and different roles in cell survival. We show that VDAC1 silencing …
channeling properties and different roles in cell survival. We show that VDAC1 silencing …
[HTML][HTML] VDAC isoforms in mammals
A Messina, S Reina, F Guarino, V De Pinto - Biochimica et Biophysica Acta …, 2012 - Elsevier
VDACs (Voltage Dependent Anion selective Channels) are a family of pore-forming proteins
discovered in the mitochondrial outer membrane. In the animal kingdom, mammals show a …
discovered in the mitochondrial outer membrane. In the animal kingdom, mammals show a …
Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene …
Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's
disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD. …
disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD. …
[HTML][HTML] Characterization of human VDAC isoforms: a peculiar function for VDAC3?
V De Pinto, F Guarino, A Guarnera, A Messina… - … et Biophysica Acta (BBA …, 2010 - Elsevier
VDACs are a family of pore-forming proteins mainly located in the mitochondrial outer
membrane. In mammals three isoforms exist. In this work we review the information available …
membrane. In mammals three isoforms exist. In this work we review the information available …
[HTML][HTML] Voltage-dependent anion-selective channel (VDAC) in the plasma membrane
Voltage-dependent anion channels (VDACs) have originally been characterized as mitochondrial
porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs …
porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs …
[HTML][HTML] Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis
F Tomasello, A Messina, L Lartigue, L Schembri… - Cell research, 2009 - nature.com
Voltage-dependent anion channel (VDAC) 1 is the main channel of the mitochondrial outer
membrane (MOM) and it has been proposed to be part of the permeability transition pore (…
membrane (MOM) and it has been proposed to be part of the permeability transition pore (…
Reducing ribosomal protein S6 kinase 1 expression improves spatial memory and synaptic plasticity in a mouse model of Alzheimer's disease
…, DM Shaw, D Turner, L Ma, A Messina… - Journal of …, 2015 - Soc Neuroscience
Aging is the most important risk factor associated with Alzheimer's disease (AD); however,
the molecular mechanisms linking aging to AD remain unclear. Suppression of the ribosomal …
the molecular mechanisms linking aging to AD remain unclear. Suppression of the ribosomal …
[HTML][HTML] Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm …
…, V De Pinto, VA Aires, X Schneider, A Messina… - Journal of Biological …, 2004 - ASBMB
Outer dense fibers (ODF) are specific subcellular components of the sperm flagellum. The
functions of ODF have not yet been clearly elucidated. We have investigated the protein …
functions of ODF have not yet been clearly elucidated. We have investigated the protein …
[HTML][HTML] ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS
Mitochondrial dysfunction and the loss of mitophagy, aimed at recycling irreversibly
damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal …
damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal …