Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored
phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4 + …

Here, using single-cell RNA sequencing, we examine the stromal compartment in murine
melanoma and draining lymph nodes (LNs) at points across tumor development, providing …

Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a
commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid …

Metastatic colonization relies on interactions between disseminated cancer cells and the
microenvironment in secondary organs. Here, we show that disseminated breast cancer cells …

Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical
structural support and regulate immunity, tolerance and the transport properties of LNs. For …

Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients.
However, the majority don’t respond to immune therapy. Across different tumor types, pre-…

Disseminated cancer cells frequently lodge near vasculature in secondary organs. However,
our understanding of the cellular crosstalk invoked at perivascular sites is still rudimentary. …

T cell–engaging immunotherapies exert unprecedented single-agent activity in multiple
myeloma (MM), thereby putting a yet unexplored selective pressure on the clonal architecture. In …

Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms
driving immune evasion remain poorly understood. Here we show that tumors induce …

The tumor microenvironment is increasingly recognized as key player in cancer progression.
Investigating heterotypic interactions between cancer cells and their microenvironment is …