Autophagy is a major clearance route for intracellular aggregate-prone proteins causing
diseases such as Huntington's disease. Autophagy induction with the mTOR inhibitor rapamycin …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review evidence …

Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic
deposition of aggregate-prone proteins in neurons and with mitochondrial dysfunction. …

Genome-wide association studies have identified several loci associated with Alzheimer’s
disease (AD), including proteins involved in endocytic trafficking such as PICALM/CALM (…

Habituation, where a response is reduced when exposed to a continuous stimulus is one of
the simplest forms of non-associative learning and has been shown in a number of …

Autophagy is an evolutionarily conserved mechanism for protein degradation that is critical
for the maintenance of homeostasis in man. Autophagy has unexpected pleiotropic functions …

Zebrafish are becoming increasingly popular as an organism in which to model human
disease and to study the effects of small molecules on complex physiological and pathological …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy, and …

Autophagy, a major degradation process for long-lived and aggregate-prone proteins, affects
various human processes, such as development, immunity, cancer, and neurodegeneration…

Folic acid prevents 70 percent of human neural tube defects (NTDs) but its mode of action is
unclear. The deoxyuridine suppression test detects disturbance of folate metabolism in …