User profiles for Angelika N. Christ
 | Angelika N ChristSequencing Facility Manager at Univeristy of Queensland Verified email at uq.edu.au Cited by 13758 |
Genomic analyses identify molecular subtypes of pancreatic cancer
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…
Whole genomes redefine the mutational landscape of pancreatic cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …
We performed whole-genome sequencing and copy number variation (CNV) analysis of …
Whole–genome characterization of chemoresistant ovarian cancer
…, S Manning, S Idrisoglu, TJC Bruxner, AN Christ… - Nature, 2015 - nature.com
Patients with high-grade serous ovarian cancer (HGSC) have experienced little
improvement in overall survival, and standard treatment has not advanced beyond platinum-based …
improvement in overall survival, and standard treatment has not advanced beyond platinum-based …
Whole-genome landscape of pancreatic neuroendocrine tumours
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …
more sensitive detection methods, and this increase is creating challenges for clinical …
[HTML][HTML] Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
…, N Waddell, PJ Wilson, TJC Bruxner, AN Christ… - Nature …, 2014 - nature.com
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries.
A better understanding of EAC underpins efforts to improve early detection and treatment …
A better understanding of EAC underpins efforts to improve early detection and treatment …
Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …
[PDF][PDF] Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation
Cardiac differentiation of human pluripotent stem cells (hPSCs) requires orchestration of
dynamic gene regulatory networks during stepwise fate transitions but often generates …
dynamic gene regulatory networks during stepwise fate transitions but often generates …
Hypermutation in pancreatic cancer
Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation
burden and defective DNA repair are associated with response to immune checkpoint …
burden and defective DNA repair are associated with response to immune checkpoint …
Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance
…, MC Cummings, TJC Bruxner, AN Christ… - The Journal of …, 2015 - Wiley Online Library
Abstract Treatment options for patients with brain metastases ( BMs ) have limited efficacy
and the mortality rate is virtually 100%. Targeted therapy is critically under‐utilized, and our …
and the mortality rate is virtually 100%. Targeted therapy is critically under‐utilized, and our …
Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations
Heterogeneity of cell states represented in pluripotent cultures has not been described at the
transcriptional level. Since gene expression is highly heterogeneous between cells, single-…
transcriptional level. Since gene expression is highly heterogeneous between cells, single-…