Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss- and gain-of-function studies revealed both the pleiotropic action of the …

Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …

The primary cilium is a cellular organelle that is almost ubiquitous in eukaryotes, yet its
functions in vertebrates have been slow to emerge. The last fifteen years have been marked by …

Signals through the Notch receptors are used throughout development to control cellular fate
choices. Our intention here is to provide an overview of the involvement of Notch signaling …

Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder
characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as …

The development of the human cerebral cortex is an orchestrated process involving the
generation of neural progenitors in the periventricular germinal zones, cell proliferation …

Autism spectrum disorders (ASD) are a group of related neurodevelopmental syndromes
with complex genetic etiology. We identified a de novo chromosome 7q inversion disrupting …

Genetic analyses of dwarfing phenotypes resulting from targeted mutagenesis of the genes
encoding the insulin-like growth factors (IGF-I and IGF-II) and their cognate type 1 IGF …

<p id="p001">Tourette's syndrome is a common developmental neuropsychiatric disorder
characterized by chronic motor and vocal tics. Despite a strong genetic contribution, …

Gliomas represent approximately 30% of all central nervous system tumors and 80% of
malignant brain tumors 1 . To understand the molecular mechanisms underlying the malignant …